Optimal antisense target reducing INS intron 1 retention is adjacent to a parallel G quadruplex

Splice-switching oligonucleotides (SSOs) have been widely used to inhibit exon usage but antisense strategies that promote removal of entire introns to increase splicing-mediated gene expression have not been developed. Here we show reduction of INS intron 1 retention by SSOs that bind transcripts d...

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Detalles Bibliográficos
Main Authors: Kralovicova, Jana, Lages, Ana, Patel, Alpa, Dhir, Ashish, Buratti, Emanuele, Searle, Mark, Vorechovsky, Igor
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2014
Assuntos:
Synthetic Biology and Chemistry
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4081105/
https://ncbi.nlm.nih.gov/pubmed/24944197
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku507
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