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Thioflavin T Monitoring of Guanine Quadruplex Formation in the rs689-Dependent INS Intron 1
The human proinsulin gene (INS) contains a thymine-to-adenine variant (rs689) located in the 3′ splice site (3′ ss) recognition motif of the first intron. The adenine at rs689 is strongly associated with type 1 diabetes. By weakening the polypyrimidine tract, the adenine allele reduces the efficienc...
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| Publicado no: | Mol Ther Nucleic Acids |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society of Gene & Cell Therapy
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6539410/ https://ncbi.nlm.nih.gov/pubmed/31150930 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2019.04.026 |
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