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Optimal antisense target reducing INS intron 1 retention is adjacent to a parallel G quadruplex
Splice-switching oligonucleotides (SSOs) have been widely used to inhibit exon usage but antisense strategies that promote removal of entire introns to increase splicing-mediated gene expression have not been developed. Here we show reduction of INS intron 1 retention by SSOs that bind transcripts d...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4081105/ https://ncbi.nlm.nih.gov/pubmed/24944197 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku507 |
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