Activity of EGFR, mTOR and PI3K inhibitors in an isogenic breast cell line model

BACKGROUND: The epidermal growth factor receptor family is expressed in breast cancer, and agents targeting this pathway have single agent effects (e.g. traztuzumab). Development of resistance may be due to the presence of alternative pathways, particularly activation of the PI3K/Akt/MTOR pathway. W...

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Hlavní autoři: Glaysher, Sharon, Bolton, Louise M, Johnson, Penny, Torrance, Christopher, Cree, Ian A
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2014
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4080989/
https://ncbi.nlm.nih.gov/pubmed/24964744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-0500-7-397
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