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Activity of EGFR, mTOR and PI3K inhibitors in an isogenic breast cell line model
BACKGROUND: The epidermal growth factor receptor family is expressed in breast cancer, and agents targeting this pathway have single agent effects (e.g. traztuzumab). Development of resistance may be due to the presence of alternative pathways, particularly activation of the PI3K/Akt/MTOR pathway. W...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4080989/ https://ncbi.nlm.nih.gov/pubmed/24964744 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-0500-7-397 |
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