Pten loss induces autocrine FGF signaling to promote skin tumorigenesis

Inactivation of the Pten tumor suppressor negatively regulates the PI3K-mTOR pathway. In a model of cutaneous squamous cell carcinoma (SCC), we demonstrate that deletion of Pten strongly elevates Fgf10 protein levels without increasing Fgf10 transcription in vitro and in vivo. The translational acti...

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Hauptverfasser: Hertzler-Schaefer, Kristina, Mathew, Grinu, Somani, Ally-Khan, Tholpady, Sunil, Kadakia, Madhavi P., Chen, Yiping, Spandau, Dan F., Zhang, Xin
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4080841/
https://ncbi.nlm.nih.gov/pubmed/24582960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2014.01.045
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