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Pten loss induces autocrine FGF signaling to promote skin tumorigenesis
Inactivation of the Pten tumor suppressor negatively regulates the PI3K-mTOR pathway. In a model of cutaneous squamous cell carcinoma (SCC), we demonstrate that deletion of Pten strongly elevates Fgf10 protein levels without increasing Fgf10 transcription in vitro and in vivo. The translational acti...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4080841/ https://ncbi.nlm.nih.gov/pubmed/24582960 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2014.01.045 |
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