Antioxidant Enzymes Reduce DNA Damage and Early Activation of Valvular Interstitial Cells in Aortic Valve Sclerosis

OBJECTIVE: Accumulation of reactive oxygen species (ROS) and remodeling of the microstructure of the cusp characterize aortic valve sclerosis, the early phase of calcific aortic valve disease. These events are associated with activation of valvular interstitial cells (VICs) toward an osteogenic-like...

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Auteurs principaux: Branchetti, Emanuela, Sainger, Rachana, Poggio, Paolo, Grau, Juan B., Patterson-Fortin, Jeffrey, Bavaria, Joseph E., Chorny, Michael, Lai, Eric, Gorman, Robert C., Levy, Robert J., Ferrari, Giovanni
Format: Artigo
Langue:Inglês
Publié: 2012
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4080420/
https://ncbi.nlm.nih.gov/pubmed/23241403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.112.300177
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