Osteopontin-CD44v6 Interaction Mediates Calcium Deposition via Phospho-Akt in Valve Interstitial Cells From Patients With Noncalcified Aortic Valve Sclerosis

OBJECTIVE—: The activation of valve interstitial cells (VICs) toward an osteogenic phenotype characterizes aortic valve sclerosis, the early asymptomatic phase of calcific aortic valve disease. Osteopontin is a phosphorylated acidic glycoprotein that accumulates within the aortic leaflets and labels...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Arterioscler Thromb Vasc Biol
Hlavní autoři: Poggio, Paolo, Branchetti, Emanuela, Grau, Juan B., Lai, Eric K., Gorman, Robert C., Gorman, Joseph H., Sacks, Michael S., Bavaria, Joseph E., Ferrari, Giovanni
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6580848/
https://ncbi.nlm.nih.gov/pubmed/25060796
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.113.303017
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky