A Linear Relationship between Crystal Size and Fragment Binding Time Observed Crystallographically: Implications for Fragment Library Screening Using Acoustic Droplet Ejection

High throughput screening technologies such as acoustic droplet ejection (ADE) greatly increase the rate at which X-ray diffraction data can be acquired from crystals. One promising high throughput screening application of ADE is to rapidly combine protein crystals with fragment libraries. In this a...

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Bibliografiske detaljer
Main Authors: Cole, Krystal, Roessler, Christian G., Mulé, Elizabeth A., Benson-Xu, Emma J., Mullen, Jeffrey D., Le, Benjamin A., Tieman, Alanna M., Birone, Claire, Brown, Maria, Hernandez, Jesus, Neff, Sherry, Williams, Daniel, Allaire, Marc, Orville, Allen M., Sweet, Robert M., Soares, Alexei S.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2014
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4079544/
https://ncbi.nlm.nih.gov/pubmed/24988328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0101036
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