Hitting the target: fragment screening with acoustic in situ co-crystallization of proteins plus fragment libraries on pin-mounted data-collection micromeshes

Acoustic droplet ejection (ADE) is a powerful technology that supports crystallographic applications such as growing, improving and manipulating protein crystals. A fragment-screening strategy is described that uses ADE to co-crystallize proteins with fragment libraries directly on MiTeGen MicroMesh...

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Hlavní autoři: Yin, Xingyu, Scalia, Alexander, Leroy, Ludmila, Cuttitta, Christina M., Polizzo, Gina M., Ericson, Daniel L., Roessler, Christian G., Campos, Olven, Ma, Millie Y., Agarwal, Rakhi, Jackimowicz, Rick, Allaire, Marc, Orville, Allen M., Sweet, Robert M., Soares, Alexei S.
Médium: Artigo
Jazyk:Inglês
Vydáno: International Union of Crystallography 2014
Témata:
Research Papers
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4014116/
https://ncbi.nlm.nih.gov/pubmed/24816088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S1399004713034603
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