A Linear Relationship between Crystal Size and Fragment Binding Time Observed Crystallographically: Implications for Fragment Library Screening Using Acoustic Droplet Ejection

High throughput screening technologies such as acoustic droplet ejection (ADE) greatly increase the rate at which X-ray diffraction data can be acquired from crystals. One promising high throughput screening application of ADE is to rapidly combine protein crystals with fragment libraries. In this a...

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Main Authors: Cole, Krystal, Roessler, Christian G., Mulé, Elizabeth A., Benson-Xu, Emma J., Mullen, Jeffrey D., Le, Benjamin A., Tieman, Alanna M., Birone, Claire, Brown, Maria, Hernandez, Jesus, Neff, Sherry, Williams, Daniel, Allaire, Marc, Orville, Allen M., Sweet, Robert M., Soares, Alexei S.
פורמט: Artigo
שפה:Inglês
יצא לאור: Public Library of Science 2014
נושאים:
Research Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC4079544/
https://ncbi.nlm.nih.gov/pubmed/24988328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0101036
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