A Linear Relationship between Crystal Size and Fragment Binding Time Observed Crystallographically: Implications for Fragment Library Screening Using Acoustic Droplet Ejection

High throughput screening technologies such as acoustic droplet ejection (ADE) greatly increase the rate at which X-ray diffraction data can be acquired from crystals. One promising high throughput screening application of ADE is to rapidly combine protein crystals with fragment libraries. In this a...

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Autors principals: Cole, Krystal, Roessler, Christian G., Mulé, Elizabeth A., Benson-Xu, Emma J., Mullen, Jeffrey D., Le, Benjamin A., Tieman, Alanna M., Birone, Claire, Brown, Maria, Hernandez, Jesus, Neff, Sherry, Williams, Daniel, Allaire, Marc, Orville, Allen M., Sweet, Robert M., Soares, Alexei S.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2014
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4079544/
https://ncbi.nlm.nih.gov/pubmed/24988328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0101036
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