Caricamento...
Template-directed synthesis of a small molecule-antisense conjugate targeting an mRNA structure
The targeting of structural features in mRNA with specificity remains a great chemical challenge. A hairpin structure near exon 10 in the pre-mRNA encoding the tau protein controls its splicing, and dementia-causing mutations that disrupt this structure increase exon 10 splicing. We previously repor...
Salvato in:
| Autori principali: | , , |
|---|---|
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2014
|
| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4079005/ https://ncbi.nlm.nih.gov/pubmed/24691171 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bioorg.2014.03.001 |
| Tags: |
Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !
|