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Template-directed synthesis of a small molecule-antisense conjugate targeting an mRNA structure
The targeting of structural features in mRNA with specificity remains a great chemical challenge. A hairpin structure near exon 10 in the pre-mRNA encoding the tau protein controls its splicing, and dementia-causing mutations that disrupt this structure increase exon 10 splicing. We previously repor...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2014
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4079005/ https://ncbi.nlm.nih.gov/pubmed/24691171 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bioorg.2014.03.001 |
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