An alcohol-sensing site in the calcium- and voltage-gated, large conductance potassium (BK) channel

Ethanol alters BK (slo1) channel function leading to perturbation of physiology and behavior. Site(s) and mechanism(s) of ethanol–BK channel interaction are unknown. We demonstrate that ethanol docks onto a water-accessible site that is strategically positioned between the slo1 calcium-sensors and g...

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Bibliographic Details
Main Authors: Bukiya, Anna N., Kuntamallappanavar, Guruprasad, Edwards, Justin, Singh, Aditya K., Shivakumar, Bangalore, Dopico, Alex M.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2014
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4078796/
https://ncbi.nlm.nih.gov/pubmed/24927535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1317363111
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