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An alcohol-sensing site in the calcium- and voltage-gated, large conductance potassium (BK) channel

Ethanol alters BK (slo1) channel function leading to perturbation of physiology and behavior. Site(s) and mechanism(s) of ethanol–BK channel interaction are unknown. We demonstrate that ethanol docks onto a water-accessible site that is strategically positioned between the slo1 calcium-sensors and g...

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Main Authors: Bukiya, Anna N., Kuntamallappanavar, Guruprasad, Edwards, Justin, Singh, Aditya K., Shivakumar, Bangalore, Dopico, Alex M.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2014
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4078796/
https://ncbi.nlm.nih.gov/pubmed/24927535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1317363111
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