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An alcohol-sensing site in the calcium- and voltage-gated, large conductance potassium (BK) channel

Ethanol alters BK (slo1) channel function leading to perturbation of physiology and behavior. Site(s) and mechanism(s) of ethanol–BK channel interaction are unknown. We demonstrate that ethanol docks onto a water-accessible site that is strategically positioned between the slo1 calcium-sensors and g...

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Autori principali: Bukiya, Anna N., Kuntamallappanavar, Guruprasad, Edwards, Justin, Singh, Aditya K., Shivakumar, Bangalore, Dopico, Alex M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4078796/
https://ncbi.nlm.nih.gov/pubmed/24927535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1317363111
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