Toxic bile salts induce rodent hepatocyte apoptosis via direct activation of Fas

Cholestatic liver injury appears to result from the induction of hepatocyte apoptosis by toxic bile salts such as glycochenodeoxycholate (GCDC). Previous studies from this laboratory indicate that cathepsin B is a downstream effector protease during the hepatocyte apoptotic process. Because caspases...

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Publicado en:J Clin Invest
Autores principales: Faubion, William A., Guicciardi, M. Eugenia, Miyoshi, Hideyuki, Bronk, Steven F., Roberts, Patricia J., Svingen, Phyllis A., Kaufmann, Scott H., Gores, Gregory J.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 1999
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Article
Acceso en línea:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC407865/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9884343/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI4765
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