Toxic bile salts induce rodent hepatocyte apoptosis via direct activation of Fas

Cholestatic liver injury appears to result from the induction of hepatocyte apoptosis by toxic bile salts such as glycochenodeoxycholate (GCDC). Previous studies from this laboratory indicate that cathepsin B is a downstream effector protease during the hepatocyte apoptotic process. Because caspases...

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Detalhes bibliográficos

Publicado no:	J Clin Invest
Principais autores:	Faubion, William A., Guicciardi, M. Eugenia, Miyoshi, Hideyuki, Bronk, Steven F., Roberts, Patricia J., Svingen, Phyllis A., Kaufmann, Scott H., Gores, Gregory J.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Clinical Investigation 1999
Assuntos:	Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC407865/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9884343/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI4765
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