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Toxic bile salts induce rodent hepatocyte apoptosis via direct activation of Fas

Cholestatic liver injury appears to result from the induction of hepatocyte apoptosis by toxic bile salts such as glycochenodeoxycholate (GCDC). Previous studies from this laboratory indicate that cathepsin B is a downstream effector protease during the hepatocyte apoptotic process. Because caspases...

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Veröffentlicht in:J Clin Invest
Hauptverfasser: Faubion, William A., Guicciardi, M. Eugenia, Miyoshi, Hideyuki, Bronk, Steven F., Roberts, Patricia J., Svingen, Phyllis A., Kaufmann, Scott H., Gores, Gregory J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 1999
Schlagworte:
Article
Online-Zugang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC407865/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9884343/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI4765
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