Reduced angiotensinogen expression attenuates renal interstitial fibrosis in obstructive nephropathy in mice

A novel approach was employed to assess the contribution of the renin-angiotensin system (RAS) to obstructive nephropathy in neonatal mice having zero to four functional copies of the angiotensinogen gene (Agt). Two-day-old mice underwent unilateral ureteral obstruction (UUO) or sham operation; 28 d...

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Main Authors: Fern, Robert J., Yesko, Christine M., Thornhill, Barbara A., Kim, Hyung-Suk, Smithies, Oliver, Chevalier, Robert L.
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 1999
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC407859/
https://ncbi.nlm.nih.gov/pubmed/9884332
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