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DNA base excision repair activities and pathway function in mitochondrial and cellular lysates from cells lacking mitochondrial DNA

Mitochondrial DNA (mtDNA) contains higher steady-state levels of oxidative damage and mutates at rates significantly greater than nuclear DNA. Oxidative lesions in mtDNA are removed by a base excision repair (BER) pathway. All mtDNA repair proteins are nuclear encoded and imported. Most mtDNA repair...

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Main Authors: Stuart, J.A., Hashiguchi, K., Wilson, D.M., Copeland, W.C., Souza-Pinto, N.C., Bohr, V.A.
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2004
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC407819/
https://ncbi.nlm.nih.gov/pubmed/15107486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkh533
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