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Mitochondrial base excision repair assays
The main source of mitochondrial DNA (mtDNA) damage is reactive oxygen species (ROS) generated during normal cellular metabolism. The main mtDNA lesions generated by ROS are base modifications, such as the ubiquitous 8-oxoguanine (8-oxoG) lesion; however, base loss and strand breaks may also occur....
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| Main Authors: | , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2010
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2916069/ https://ncbi.nlm.nih.gov/pubmed/20188838 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymeth.2010.02.020 |
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