Grb-IR: a SH2-domain-containing protein that binds to the insulin receptor and inhibits its function.
To identify potential signaling molecules involved in mediating insulin-induced biological responses, a yeast two-hybrid screen was performed with the cytoplasmic domain of the human insulin receptor (IR) as bait to trap high-affinity interacting proteins encoded by human liver or HeLa cDNA librarie...
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| Veröffentlicht in: | Proc Natl Acad Sci U S A |
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| Hauptverfasser: | , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
1995
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| Schlagworte: | |
| Online-Zugang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC40781/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7479769/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.22.10287 |
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