Robust SH2 binding affinity indicates minimal SH3-to-SH2 communication in Grb2

Abstract Growth factor receptor–bound protein 2 (Grb2) is a modular adaptor that links activated receptor tyrosine kinases to downstream signaling pathways through its SH3–SH2–SH3 architecture. Previous studies showed that perturbations in the SH2 domain can influence ligand binding at the C-termina...

Descripció completa

Dades bibliogràfiques

Autors principals:	Eduarda Santos Ventura, Mariana Di Felice, Julian Toso, Valeria Pennacchietti, Angelo Toto, Stefano Gianni
Format:	Artigo
Idioma:	Inglês
Publicat:	BMC 2026-01-01
Col·lecció:	Biology Direct
Matèries:	Adaptor proteins Kinetics Allostery Site-directed mutagenesis
Accés en línia:	https://doi.org/10.1186/s13062-026-00729-z
Etiquetes:	Afegir etiqueta Sense etiquetes, Sigues el primer a etiquetar aquest registre!