Robust SH2 binding affinity indicates minimal SH3-to-SH2 communication in Grb2
Abstract Growth factor receptor–bound protein 2 (Grb2) is a modular adaptor that links activated receptor tyrosine kinases to downstream signaling pathways through its SH3–SH2–SH3 architecture. Previous studies showed that perturbations in the SH2 domain can influence ligand binding at the C-termina...
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| Hlavní autoři: | , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
BMC
2026-01-01
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| Edice: | Biology Direct |
| Témata: | |
| On-line přístup: | https://doi.org/10.1186/s13062-026-00729-z |
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