Anti-Retroviral Therapy Decreases but Does Not Normalize Indoleamine 2,3-Dioxygenase Activity in HIV-Infected Patients

BACKGROUND: Indoleamine 2,3-dioxygenase (IDO), which is mainly expressed in activated dendritic cells, catabolizes tryptophan to kynurenine and other downstream catabolites. It is known to be an immune mediator in HIV pathogenesis. The impact of anti-retroviral therapy on its activity has not been w...

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Detaylı Bibliyografya
Asıl Yazarlar: Chen, Jun, Shao, Jiasheng, Cai, Rentian, Shen, Yinzhong, Zhang, Renfang, Liu, Li, Qi, Tangkai, Lu, Hongzhou
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2014
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4077698/
https://ncbi.nlm.nih.gov/pubmed/24983463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0100446
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