Desipramine decreases expression of human and murine indoleamine-2,3-dioxygenases

Abundant evidence connects depression symptomology with immune system activation, stress and subsequently elevated levels of kynurenine. Anti-depressants, such as the tricyclic norepinephrine/serotonin reuptake inhibitor desipramine (Desip), were developed under the premise that increasing extracell...

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Udgivet i:Brain Behav Immun
Main Authors: Brooks, Alexandra K., Janda, Tiffany M., Lawson, Marcus A., Rytych, Jennifer L., Smith, Robin A., Ocampo-Solis, Cecilia, McCusker, Robert H.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5382643/
https://ncbi.nlm.nih.gov/pubmed/28212884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbi.2017.02.010
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