Central leptin replacement enhances chemorespiratory responses in leptin-deficient mice independent of changes in body weight

Previous studies showed that leptin-deficient (ob/ob) mice develop obesity and impaired ventilatory responses to CO(2) ([Formula: see text] − CO(2)). In this study, we examined if leptin replacement improves chemorespiratory responses to hypercapnia (7 % CO(2)) in ob/ob mice and if these effects wer...

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Bibliografiske detaljer
Main Authors: Bassi, Mirian, Giusti, Humberto, Leite, Cristiane Mota, Anselmo-Franci, Janete A., do Carmo, Jussara M., da Silva, Alexandre A., Hall, John E., Colombari, Eduardo, Glass, Mogens L.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4077668/
https://ncbi.nlm.nih.gov/pubmed/22585210
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00424-012-1111-1
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