Characterization of 2-(methylamino)alkanoic acid capacity to restrict blood–brain phenylalanine transport in Pah(enu2) mice: Preliminary findings()

BACKGROUND: Our laboratory seeks a pharmacotherapeutic intervention for PKU that utilizes non-physiological amino acids (NPAAs) to block the accumulation of phenylalanine (Phe) in the brain. In previous studies (Vogel et al. 2013), methylation of the amino group of 2-aminoisobutyrate (AIB) provided...

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Detalhes bibliográficos
Main Authors: Vogel, Kara R., Arning, Erland, Wasek, Brandi L., Bottiglieri, Teodoro, Gibson, K. Michael
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4077276/
https://ncbi.nlm.nih.gov/pubmed/23999161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymgme.2013.08.004
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