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NON-PHYSIOLOGICAL AMINO ACID (NPAA) THERAPY TARGETING BRAIN PHENYLALANINE REDUCTION: PILOT STUDIES IN PAH(ENU2) MICE

Transport of large neutral amino acids (LNAA) across the blood brain barrier (BBB) is facilitated by the L-type amino acid transporter, LAT1. Peripheral accumulation of one LNAA (e.g., phenylalanine (phe) in PKU) is predicted to increase uptake of the offending amino acid to the detriment of others,...

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Detalhes bibliográficos
Main Authors: Vogel, Kara R., Arning, Erland, Wasek, Brandi L., Bottiglieri, Teodoro, Gibson, K. Michael
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3654543/
https://ncbi.nlm.nih.gov/pubmed/22976763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10545-012-9524-8
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