Acute Administration of l-Dopa Induces Changes in Methylation Metabolites, Reduced Protein Phosphatase 2A Methylation, and Hyperphosphorylation of Tau Protein in Mouse Brain

Folate deficiency and hypomethylation have been implicated in a number of age-related neurodegenerative disorders including dementia and Parkinson's disease (PD). Levodopa (l-dopa) therapy in PD patients has been shown to cause an increase in plasma total homocysteine as well as depleting cellu...

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Detalhes bibliográficos
Main Authors: Bottiglieri, Teodoro, Arning, Erland, Wasek, Brandi, Nunbhakdi-Craig, Viyada, Sontag, Jean-Marie, Sontag, Estelle
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2012
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3422683/
https://ncbi.nlm.nih.gov/pubmed/22764226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0125-12.2012
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