Physiological competition of brain phenylalanine accretion: Initial pharmacokinetic analyses of aminoisobutyric and methylaminoisobutyric acids in Pah(enu2 −/−) mice

OBJECTIVE: Initial studies on the use of non-physiological amino acids (NPAAs) to block the accretion of Phe in the brain of Pah(enu2 −/−) mice revealed that 2-aminoisobutyrate (AIB) and N-methyl-2-aminoisobutyrate (MAIB) were promising lead compounds whose pharmacokinetic parameters warranted inves...

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Detalhes bibliográficos
Publicado no:Mol Genet Metab Rep
Main Authors: Vogel, Kara R., Ainslie, Garrett R., Phillips, Brian, Arning, Erland, Bottiglieri, Teodoro, Shen, Danny D., Gibson, K. Michael
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2015
Assuntos:
SI:Therapy
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4478616/
https://ncbi.nlm.nih.gov/pubmed/26120559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymgmr.2015.03.009
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