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Assessment of a novel multi-array normalization method based on spike-in control probes suitable for microRNA datasets with global decreases in expression

BACKGROUND: High-quality expression data are required to investigate the biological effects of microRNAs (miRNAs). The goal of this study was, first, to assess the quality of miRNA expression data based on microarray technologies and, second, to consolidate it by applying a novel normalization metho...

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Bibliografiske detaljer
Main Authors: Sewer, Alain, Gubian, Sylvain, Kogel, Ulrike, Veljkovic, Emilija, Han, Wanjiang, Hengstermann, Arnd, Peitsch, Manuel C, Hoeng, Julia
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4077261/
https://ncbi.nlm.nih.gov/pubmed/24886675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-0500-7-302
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