Assessment of a novel multi-array normalization method based on spike-in control probes suitable for microRNA datasets with global decreases in expression

BACKGROUND: High-quality expression data are required to investigate the biological effects of microRNAs (miRNAs). The goal of this study was, first, to assess the quality of miRNA expression data based on microarray technologies and, second, to consolidate it by applying a novel normalization metho...

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Hlavní autoři: Sewer, Alain, Gubian, Sylvain, Kogel, Ulrike, Veljkovic, Emilija, Han, Wanjiang, Hengstermann, Arnd, Peitsch, Manuel C, Hoeng, Julia
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2014
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4077261/
https://ncbi.nlm.nih.gov/pubmed/24886675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-0500-7-302
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