Cyclin D1-CDK4 Controls Glucose Metabolism Independently of Cell Cycle Progression

Insulin constitutes a major evolutionarily conserved hormonal axis for maintaining glucose homeostasis(1-3); dysregulation of this axis causes diabetes(2,4). PGC-1α links insulin signaling to the expression of glucose and lipid metabolic genes(5-7). GCN5 acetylates PGC-1α and suppresses its transcri...

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Detalhes bibliográficos
Main Authors: Lee, Yoonjin, Dominy, John E., Choi, Yoon Jong, Jurczak, Michael, Tolliday, Nicola, Camporez, Joao Paulo, Chim, Helen, Lim, Ji-Hong, Ruan, Hai-Bin, Yang, Xiaoyong, Vazquez, Francisca, Sicinski, Piotr, Shulman, Gerald I., Puigserver, Pere
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4076706/
https://ncbi.nlm.nih.gov/pubmed/24870244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature13267
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