CNS myelin induces regulatory functions of DC-SIGN–expressing, antigen-presenting cells via cognate interaction with MOG

Myelin oligodendrocyte glycoprotein (MOG), a constituent of central nervous system myelin, is an important autoantigen in the neuroinflammatory disease multiple sclerosis (MS). However, its function remains unknown. Here, we show that, in healthy human myelin, MOG is decorated with fucosylated N-gly...

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Autors principals: García-Vallejo, J.J., Ilarregui, J.M., Kalay, H., Chamorro, S., Koning, N., Unger, W.W., Ambrosini, M., Montserrat, V., Fernandes, R.J., Bruijns, S.C.M., van Weering, J.R.T., Paauw, N.J., O’Toole, T., van Horssen, J., van der Valk, P., Nazmi, K., Bolscher, J.G.M., Bajramovic, J., Dijkstra, C.D., ’t Hart, B.A., van Kooyk, Y.
Format: Artigo
Idioma:Inglês
Publicat: The Rockefeller University Press 2014
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4076586/
https://ncbi.nlm.nih.gov/pubmed/24935259
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20122192
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