CNS myelin induces regulatory functions of DC-SIGN–expressing, antigen-presenting cells via cognate interaction with MOG

Myelin oligodendrocyte glycoprotein (MOG), a constituent of central nervous system myelin, is an important autoantigen in the neuroinflammatory disease multiple sclerosis (MS). However, its function remains unknown. Here, we show that, in healthy human myelin, MOG is decorated with fucosylated N-gly...

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Autores principales: García-Vallejo, J.J., Ilarregui, J.M., Kalay, H., Chamorro, S., Koning, N., Unger, W.W., Ambrosini, M., Montserrat, V., Fernandes, R.J., Bruijns, S.C.M., van Weering, J.R.T., Paauw, N.J., O’Toole, T., van Horssen, J., van der Valk, P., Nazmi, K., Bolscher, J.G.M., Bajramovic, J., Dijkstra, C.D., ’t Hart, B.A., van Kooyk, Y.
Formato: Artigo
Lenguaje:Inglês
Publicado: The Rockefeller University Press 2014
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4076586/
https://ncbi.nlm.nih.gov/pubmed/24935259
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20122192
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