The linear ubiquitin assembly complex (LUBAC) is essential for NLRP3 inflammasome activation

Linear ubiquitination is a newly discovered posttranslational modification that is currently restricted to a small number of known protein substrates. The linear ubiquitination assembly complex (LUBAC), consisting of HOIL-1L, HOIP, and Sharpin, has been reported to activate NF-κB–mediated transcript...

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Main Authors: Rodgers, Mary A., Bowman, James W., Fujita, Hiroaki, Orazio, Nicole, Shi, Mude, Liang, Qiming, Amatya, Rina, Kelly, Thomas J., Iwai, Kazuhiro, Ting, Jenny, Jung, Jae U.
Format: Artigo
Jezik:Inglês
Izdano: The Rockefeller University Press 2014
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4076580/
https://ncbi.nlm.nih.gov/pubmed/24958845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20132486
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