Quantitative quadruple-label immunofluorescence of mitochondrial and cytoplasmic proteins in single neurons from human midbrain tissue

BACKGROUND: Respiratory chain (RC) deficiencies are found in primary mtDNA diseases. Focal RC defects are also associated with ageing and neurodegenerative disorders, e.g. in substantia nigra (SN) neurons from Parkinson's disease patients. In mitochondrial disease and ageing, mtDNA mutational l...

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Autori principali: Grünewald, Anne, Lax, Nichola Z., Rocha, Mariana C., Reeve, Amy K., Hepplewhite, Philippa D., A. Rygiel, Karolina, Taylor, Robert W., Turnbull, Doug M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier/North-Holland Biomedical Press 2014
Soggetti:
Basic Neuroscience
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4076514/
https://ncbi.nlm.nih.gov/pubmed/24880043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jneumeth.2014.05.026
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