A Herpes Simplex Virus 2 (HSV-2) Glycoprotein D-expressing Nonreplicating Dominant-Negative HSV-2 Virus Vaccine Is Superior to a gD2 Subunit Vaccine against HSV-2 Genital Infection in Guinea Pigs

We recently constructed a novel non-replicating dominant-negative HSV-2 recombinant viral vaccine (CJ2-gD2) capable of expressing various HSV-2 antigens that are dominant targets of HSV-2-specific CD8 T-cell response. Importantly, CJ2-gD2 expresses gD2, the HSV-2 major antigen glycoprotein D, as eff...

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Bibliographic Details
Main Authors: Zhang, Pengwei, Xie, Lining, Balliet, John W., Casimiro, Danilo R., Yao, Feng
Format: Artigo
Language:Inglês
Published: Public Library of Science 2014
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4076306/
https://ncbi.nlm.nih.gov/pubmed/24979708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0101373
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