Sclerostin Antibody Inhibits Skeletal Deterioration Due to Reduced Mechanical Loading

Sclerostin, a product of the SOST gene produced mainly by osteocytes, is a potent negative regulator of bone formation that appears to be responsive to mechanical loading, with SOST expression increasing following mechanical unloading. We tested the ability of a murine sclerostin antibody (SclAbII)...

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Main Authors: Spatz, Jordan M, Ellman, Rachel, Cloutier, Alison M, Louis, Leeann, van Vliet, Miranda, Suva, Larry J, Dwyer, Denise, Stolina, Marina, Ke, Hua Zhu, Bouxsein, Mary L
Format: Artigo
Jezik:Inglês
Izdano: 2013
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4076162/
https://ncbi.nlm.nih.gov/pubmed/23109229
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbmr.1807
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