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Sclerostin Antibody Inhibits Skeletal Deterioration Due to Reduced Mechanical Loading
Sclerostin, a product of the SOST gene produced mainly by osteocytes, is a potent negative regulator of bone formation that appears to be responsive to mechanical loading, with SOST expression increasing following mechanical unloading. We tested the ability of a murine sclerostin antibody (SclAbII)...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4076162/ https://ncbi.nlm.nih.gov/pubmed/23109229 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbmr.1807 |
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