Sclerostin inhibition reverses systemic, periarticular and local bone loss in arthritis

OBJECTIVE: To test whether inhibition of sclerostin by a targeted monoclonal antibody (Scl-Ab) protects from bone and cartilage damage in inflammatory arthritis. Sclerostin is a potent inhibitor of bone formation and may be responsible for the low level of bone repair in patients with rheumatoid art...

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Detalhes bibliográficos
Main Authors: Chen, Xiao-Xiang, Baum, Wolfgang, Dwyer, Denise, Stock, Michael, Schwabe, Kay, Ke, Hua-Zhu, Stolina, Marina, Schett, Georg, Bozec, Aline
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Publishing Group 2013
Assuntos:
Basic and Translational Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3786639/
https://ncbi.nlm.nih.gov/pubmed/23666928
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/annrheumdis-2013-203345
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