Declining NAD(+) Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging

Ever since eukaryotes subsumed the bacterial ancestor of mitochondria, the nuclear and mitochondrial genomes have had to closely coordinate their activities, as each encode different subunits of the oxidative phosphorylation (OXPHOS) system. Mitochondrial dysfunction is a hallmark of aging, but its...

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主要な著者: Gomes, Ana P., Price, Nathan L., Ling, Alvin J.Y., Moslehi, Javid J., Montgomery, Magdalene K., Rajman, Luis, White, James P., Teodoro, João S., Wrann, Christiane D., Hubbard, Basil P., Mercken, Evi M., Palmeira, Carlos M., de Cabo, Rafael, Rolo, Anabela P., Turner, Nigel, Bell, Eric L., Sinclair, David A.
フォーマット: Artigo
言語:Inglês
出版事項: 2013
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4076149/
https://ncbi.nlm.nih.gov/pubmed/24360282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2013.11.037
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