Berberine protects against high fat diet-induced dysfunction in muscle mitochondria by inducing SIRT1-dependent mitochondrial biogenesis

Berberine (BBR) has recently been shown to improve insulin sensitivity in rodent models of insulin resistance. Although this effect was explained partly through an observed activation of AMP-activated protein kinase (AMPK), the upstream and downstream mediators of this phenotype were not explored. H...

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Bibliographic Details
Main Authors: Gomes, Ana P., Duarte, Filipe V., Nunes, Patricia, Hubbard, Basil P., Teodoro, João S., Varela, Ana T., Jones, John G., Sinclair, David A., Palmeira, Carlos M., Rolo, Anabela P.
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3366688/
https://ncbi.nlm.nih.gov/pubmed/22027215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbadis.2011.10.008
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