SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function

Resveratrol induces mitochondrial biogenesis and protects against metabolic decline but whether SIRT1 mediates these benefits is the subject of debate. To circumvent the developmental defects of germ-line SIRT1 knockouts, we have developed the first inducible system that permits whole-body deletion...

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Main Authors: Price, Nathan L., Gomes, Ana P., Ling, Alvin J.Y., Duarte, Filipe V., Martin-Montalvo, Alejandro, North, Brian J., Agarwal, Beamon, Ye, Lan, Ramadori, Giorgio, Teodoro, Joao S., Hubbard, Basil P., Varela, Ana T., Davis, James G., Varamini, Behzad, Hafner, Angela, Moaddel, Ruin, Rolo, Anabela P., Coppari, Roberto, Palmeira, Carlos M., de Cabo, Rafael, Baur, Joseph A., Sinclair, David A.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3545644/
https://ncbi.nlm.nih.gov/pubmed/22560220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2012.04.003
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