Combined Troponin I Ser-150 and Ser-23/24 Phosphorylation Sustains Thin Filament Ca(2+) Sensitivity and Accelerates Deactivation in an Acidic Environment()

The binding of Ca(2+) to troponin C (TnC) in the troponin complex is a critical step regulating the thin filament, the actin-myosin interaction and cardiac contraction. Phosphorylation of the troponin complex is a key regulatory mechanism to match cardiac contraction to demand. Here we demonstrate p...

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Detalhes bibliográficos
Main Authors: Nixon, Benjamin R., Walton, Shane D., Zhang, Bo, Brundage, Elizabeth A., Little, Sean C., Ziolo, Mark T., Davis, Jonathan P., Biesiadecki, Brandon J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4075059/
https://ncbi.nlm.nih.gov/pubmed/24657721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2014.03.010
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