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Mst1 promotes cardiac myocyte apoptosis through phosphorylation and inhibition of Bcl-xL
The Hippo pathway, evolutionarily conserved from flies to mammals, promotes cell death and inhibits cell proliferation to regulate organ size. The core component of this cascade, Mst1 in mammalian cells, is sufficient to promote apoptosis. However, the mechanisms underlying both its activation and i...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4074544/ https://ncbi.nlm.nih.gov/pubmed/24813943 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2014.04.007 |
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