mTORC2 regulates cardiac response to stress by inhibiting MST1

The mTOR and Hippo pathways have recently emerged as the major signaling transduction cascades regulating organ size and cellular homeostasis. However, direct crosstalk between two pathways is yet to be determined. Here we demonstrate that mTORC2 is a direct negative regulator of the MST1 kinase, a...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Sciarretta, Sebastiano, Zhai, Peiyong, Maejima, Yasuhiro, Del Re, Dominic P., Nagarajan, Narayani, Yee, Derek, Liu, Tong, Magnuson, Mark A., Volpe, Massimo, Frati, Giacomo, Li, Hong, Sadoshima, Junichi
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4417361/
https://ncbi.nlm.nih.gov/pubmed/25843706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.03.010
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