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Rheb is a critical regulator of autophagy during myocardial ischemia: pathophysiological implications in obesity and metabolic syndrome

BACKGROUND: Rheb is a GTP-binding protein that promotes cell survival and mediates the cellular response to energy deprivation (ED). The role of Rheb in the regulation of cell survival during ED has not been investigated in the heart. METHODS AND RESULTS: Rheb is inactivated during cardiomyocyte (CM...

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Main Authors: Sciarretta, Sebastiano, Zhai, Peiyong, Shao, Dan, Maejima, Yasuhiro, Robbins, Jeffrey, Volpe, Massimo, Condorelli, Gianluigi, Sadoshima, Junichi
Formato: Artigo
Idioma:Inglês
Publicado: 2012
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3337789/
https://ncbi.nlm.nih.gov/pubmed/22294621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.111.078212
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